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1st DFG-Research Group Symposium
on

"Keratinocytes - Proliferation and Differentiation in the Epidermis"

Bonn, October 5 and 6, 2001


				Barrier Function
Epidermal Embryogenesis
	Epidermal Connexins
			Langerhans Cells in Immune Defense
IKeratin in Genetic Diseases
			Extracellular Proteolysis and Migration
	Keratinocyte Stem Cells
		Regulation of Cell Growth and Wound Repair

Guest Speakers:	George Vann Bennett, Michele De Luca, Reinhard Fässler, Werner W. Franke, Norbert Fusenig, Paul Martin, Irwin Mc Lean, Marie-Caroline Dieu-Nosjean, Maja Ponec, Gabriela Richard, Sabine Werner
Organizers:	Thomas Bieber, Klaudia Brix, Volker Herzog, Hans Wilhelm Kaiser, Thomas Magin, Markus Nöthen, Konrad Sandhoff, Klaus Willecke

Universitäts-Club Bonn,
Konviktstr. 9, 53113 Bonn,
Tel.: 0228/72960, Fax: 0228/7296100,
email: office@uniclub-bonn.de

Hotel "Schwan"
Mozartstr. 24,
53115 Bonn,
Tel: 0228/96303-0, Fax: 0228/651793

Airport-Connections:

Frankfurt/Airport:
Connection to Bonn by Intercity (Railway from Frankfurt/Airport to Bonn, main station). This train goes every hour through the specteculary beautiful Rhine Valley and takes about one hour and 40 minutes. Usually, the price is included in your flight ticket.

Konrad Adenauer-Airport Köln/Bonn:
Connections to Bonn mainstation by the Airport Bus which leaves every 20 minutes directly in front of the Airport and which takes about 30 minutes. The costs (DM 10) are not included in your ticket. If we know the time of your arrival we will try to pick you up, personally.

Symposium
"Keratinocytes - Proliferation and Differentiation in the Epidermis"
University of Bonn, University Club

PROGRAM

Friday, October 5

Saturday, October 6

9:00 - 9:40 9:45 - 10:00	Reinhard Fässler (Lund) THE ROLE OF INTEGRINS FOR KERATINOCYTE FUNCTION Thomas Magin (Bonn) STRECHED: ANALYSIS OF GFP-TAGGED KERATIN MUTANTS IN LIVE CELLS
10:00 - 10:45 10:45 - 11:00	George Vann Bennett (Durham, NC) ANKYRINS: MOLECULAR KEYS TO THE CELLULAR CODE FOR DIRECTING ION CHANNELS TO SITES OF PHYSIOLOGICAL FUNCTION Hans Wilhelm Kaiser (Bonn) ANKYRIN IN DER EPIDERMIS
11:00 - 12:30	POSTERSESSION
12:30 - 13:30	Lunch
13:30 - 14:15 14:15 - 14:30	Irwin McLean (Dundee) KERATINS: PROTEIN-PROTEIN INTERACTIONS AND GENETIC DISEASES Markus Nöthen (Bonn) HAIRLESS MUTATIONS IN GENETIC DISEASES
14:30 - 15:00	Coffee Break
15:00 - 15:45 15:45 - 16:00	Gabriela Richard (Philadephia, PA) CONNEXIN MUTATIONS IN HUMAN SKIN DISORDERS AND THEIR FUNCTIONL CONSEQUENCES Klaus Willecke (Bonn) EXPRESSION CHANGES OF CONNEXINS IN MOUSE EPIDERMIS DURING WOUND HEALING
16:00 - 16:45 16:45 - 17:00	Maja Ponec (LEIDEN) FORMATION OF BARRIER FUNCTION IN RECONSTRUCTED EPIDERMIS Konrad Sandhoff (Bonn) CERAMIDE FORMATION IN DIFFERENTIATING KERATINOCYTES
17:00 - 17:30	Coffee Break
17:30 - 18:30	Future Perspectives in Keratinocyte Research Michele De Luca (Roma) KERATINOCYTE STEM CELLS: FROM CLONES TO CLINICS
19:30	Dinner, at the "Lese" Society and Restaurant open end

13:00 - 13:10	Opening
13:10 - 14:10	Opening Lecture Paul Martin (London) EPITHELIAL MORPHOGENESIS AND REPAIR IN THE EMBRYO
14:10 - 14:30	Coffee break
14:30 - 15:15 14:15 - 15:30	Sabine Werner (Zürich) THE KGF FAMILY: IMPORTANT REGULATORS OF KERATINOCYTE PROLIFERATION, DIFFERENTIATION AND SURVIVAL Volker Herzog (Bonn) ROLE OF sAPP IN THE REGULATION OF KERATINOCYTE GROWTH, MIGRATION AND CELL DEATH
15:30 - 16:15 16:15 - 16:30	Norbert Fusenig (Heidelberg) MESENCHYMAL REGULATION OF KERATINOCYTE GROWTH AND DIFFERENTIATION BY DOUBLE PARACRINE MECHANISMS Klaudia Brix (Bonn) CONTRIBUTION OF CYSTEINE PROTEINASES TO ECM-REMODELLING DURING KERATINOCYTE MIGRATION
16:30 - 17:15 17:15 - 17:30	Marie Caroline Dieu-Nosjean (Paris) MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA IS THE MOST POTENT CHEMOKINE IN ATTRACTING LANGERHANS CELL PRECURSORS, AND IS UP-REGULATED IN PSORIASIS. Thomas Bieber (Bonn) MIGRATION OF LANGERHANS CELLS INTO THE EPIDERMIS
17:30 - 18:00	Coffee Break
18:00 - 19:00	Evening lecture Werner W. Franke (Heidelberg) BEYOND AND UNDER THE SKIN: THE EPIDERMIS - A CONTINUAL SOURCE OF DISCOVERIES OF MOLECULES AND STRUCTURES ALSO IMPORTANT IN OTHER ORGANS
19:00	Dinner, at Poppelsdorf Castle, Stucksaal open end