"Keratinocyten - Proliferation
und differenzierte Leistung
in der Epidermis"
| DFG-Forschergruppe
"Keratinocyten - Proliferation
|
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Open Positions
Im Rahmen der von der DFG geförderten Forschergruppe "Keratinocyten" ist eine
1 Diplomandenstelle (stud. Hilfskraftstelle)
zu besetzen.
Fragestellung:
Knock-out Mäuse zur Untersuchung von Keratinocyten-Proliferation, -Migration und -Apoptose.
Spektrum der Techniken:
- Etablierung einer Mäusezucht mit vorhandenem Knock-out(Heber et al., J Neurosci, 20 (21), 7951-7963, 2000; von Koch et al., Neurobiol Aging, 18 (6), 661-669, 1997).
- Zellkultur
- Proteinbiochemie
- Molekularbiologie
- Konfokale Laser-Scan-Mikroskopie
- Hochauflösende Feldemissions-Rasterelektronenmikroskopie
Ansprechpartner:
Prof. Dr. V. Herzog, Dipl. Biol. C. Twiesselmann, Dipl. Biol. T. Quast
Teilprojekt Herzog
Bezahlte Diplomarbeiten Stellen inzwischen vergeben
Für die Mitarbeit in der von der DFG finanzierten Forschergruppe
"Keratinocyten" sind 2 studentische Hilfskraftstellen zu besetzen.
Inhalt der Arbeiten sind unter anderem molekularbiologische und morphologische
Methoden zum Nachweis der Expression von APP (Alzheimer-amyloid-precursor-protein)
in menschlicher Haut.
Ansprechpartner: Prof. Herzog
3 postdoctoral positions (BAT IIa)
The special research group "Keratinocyte Proliferation and Differentiation" is a new, interdisciplinary research initiative funded by the German Research Association (DFG) comprised of seven groups working in cell biology, molecular genetics, dermatology, biochemistry and human genetics. Our major aim is to analyze molecular mechanisms involved in keratinocyte proliferation and differentiation, using mouse genetics, cell culture and biochemistry.
Three postdoctoral positions for 3 years in the first instance are immediately available to join one of the following research teams.
Prof. Thomas Bieber, Dept. of Dermatology, Sigmund-Freud-Str. 25, D-53105 Bonn; e-mail thomas.bieber@meb.uni-bonn.de
Our group is focusing on the immunobiology of epidermal antigen presenting dendritic cells. We are currently establishing an in vitro model to investigate the mechanisms involved in the regulation and migration of circulating precursors cells into the epidermis using a 3 compartments reconstituted skin.
PD Dr. Thomas Magin, Division of Molec. Genetics, Roemerstrasse 164, D-53117 Bonn; e-mail t.magin@uni-bonn.de
Our group is engaged in the functional analysis of keratins using standard and refined gene targeting methods (eg. Porter et al., JCB 132; Reichelt et al., JCS 110, JID 113; Magin et al., JCB 140). The new project offers to establish gene targeting in cultured human keratinocytes or to study keratin function in transgenic/knockout mice in order to clarify the specific functions of keratins in epidermis. Candidates should be experienced in either gene targeting/cell culture, mouse genetics or skin biology.
Prof. Klaus Willecke, Div. of Molec. Genetics, Roemerstrasse 164, D-53117 Bonn; e-mail genetik@uni-bonn.de
We are aiming to study the function of gap junction mediated intercellular communication in the mouse epidermis by investigating keratinocyte specific and/or inducible knock-out mice of connexin genes. We want to clarify to which extent differentiation and proliferation in the epidermis are dependent on the function of connexin genes. For recent results of our work on connexin genes, see www.uni-bonn.de/genetik/
Applications, including CV and names of two referees should be received by the corresponding group leader not later than Feb. 25, 2000.
| Uni-Bonn | Biologie | Zellbiologie | BFB | DFG-Forschergruppe |